The worst thing God can do to you in this world is not pain. It's not karma either. The worst outcome would be a constricted heart. Man is weak. Khaaki is weak. We require guidance towards our goals and we need to open ourselves for this guidance. We need Him to walk us down the path we need to go to.
Having dreams and goals is natural for any conscious man. But these goals are merely a direction, not the path you walk on. Letting go of the thought of having them, following the path you build and leaving the outcome to the Lord is the answer. That is to become who you want to be for your purpose and leaving the purpose itself to Him.
But when Khaaki stray from belief. The creator constricts their chests, blocking the light of guidance from entering their hearts. What use has a man of knowledge of his path when he doesn't have the sight to move along. Blinded, he deludes himself and misleads himself to the wrong path.
Guidance is what man needs the most. On our own we delude ourselves into devastating consequence. Our delusions ruin us and those around us like a parasite, they keep us uninformed of what's happening.
So when you pray, ask for guidance. May your desire be worldly or may it be God himself. Your knowledge determines the magnitude of the path you seek, Guidance determines the direction you shall precede.